Gambaran Pengetahuan Keluarga Tentang Cara Penanganan Radang Sendi (Osteoarthritis) Di Komunitas

Background: Osteoartritis (OA) is degenerative diseases that were closely related with destruction cartilages joints, where osteoartritis often occurs in elderly and middle-aged. The increasing number of osteoarthritis influenced improper handling. As a family with oateoartritis family have knowledge about the handling of osteoarthritis. Research Objective: This study aims to in order to understand the bahaiman pengatahuan family discussion about how to handle this problem osteoarthritis. Benefits of Research: Can know whether in the work area of Puskesmas Pajang Surakarta posted , how to handle this oa lot family knowledge is good , enough or less. Research Methods: The kind of research it is an expression of quantitative research with a design research descriptive of simple to had a clear grasp of the level of knowledge of family discussion about how to handle this problem of arthritis (osteoarthritis) living in their community. The sample are a family where one of its members suffer osteoarthritis that is in the work area of Puskesmas Pajang Surakarta and in select based on the criteria samples. Measurements used for measuring the degree knowledge use 20 question made by researchers. Research Result: Statistical analysis to come by the results of, of respondents 19 40 there are people (47,5 %) less, of knowledge respondents who have quite as much as the level of knowledge 17 ( 42,5 % ) and respondents who has a good knowledge of 4 people (10%). Conclusion: Analysis concluded that family in knowledge in the work area Puskesmas Pajang Surakarta is very weak. Keywords: Osteoarthritis , the family knowledge , how to handle this , community

The role of language skills in interactive social book search sessions

When searching for books, people frequently have to deal with content that is in a language different from their own. However, research on multilingual systems has generally focused on the user interface's language rather than the content language. In this paper, we describe and compare early results from the multilingual aspects in the Interactive Social Book Search (iSBS) task at CLEF 2014 and 2015. A preliminary analysis of usage patterns for native English and non-native English speakers indicates an influence of language skills on search behaviour during goal-oriented and casual leisure tasks. Based on previous experiences and results, strengths and challenges of IIR studies are discussed

Germline selection shapes human mitochondrial DNA diversity.

Approximately 2.4% of the human mitochondrial DNA (mtDNA) genome exhibits common homoplasmic genetic variation. We analyzed 12,975 whole-genome sequences to show that 45.1% of individuals from 1526 mother-offspring pairs harbor a mixed population of mtDNA (heteroplasmy), but the propensity for maternal transmission differs across the mitochondrial genome. Over one generation, we observed selection both for and against variants in specific genomic regions; known variants were more likely to be transmitted than previously unknown variants. However, new heteroplasmies were more likely to match the nuclear genetic ancestry as opposed to the ancestry of the mitochondrial genome on which the mutations occurred, validating our findings in 40,325 individuals. Thus, human mtDNA at the population level is shaped by selective forces within the female germ line under nuclear genetic control, which ensures consistency between the two independent genetic lineages.NIHR, Wellcome Trust, MRC, Genomics Englan

PENGARUH KONSENTRASI EKSTRAK ETANOL BUAH DELIMA (Punica granatum L.) TERHADAP PENINGKATAN APOPTOSIS DAN HAMBATAN INVASI SEL KANKER LIDAH MANUSIA SP-C1 IN VITRO

Oral tongue squamous cell carcinoma (OTSCC) is characterized by high degree of cell invasion and metastasis to regional and distant lymph node. Oral cancer treatment is categorized as a difficult disease to treat, although it has been to treat by holistic procedures. New strategies were needed to suppress the growth of oral cancer cell by a herbal medicine ex. Pomegranate fruit. The aim of the study is to investigate the effect of pomegranate ethanol extract on an human oral tongue cancer cell line SP-C1 through apoptosis induction and inhibition of cell invasion. The laboratory experimental study was conducted in the study. Furthermore, to detect apoptosis induction, double staining included ethidium bromide and acridine orange was carried out after 24 hours incubation. Fluorescence microscopy was used for counting the cell. Viable cells would be stained green and apoptotic cell would be stained yellow. Furthermore, to detect inhibition of cell invasion staining with keratin / hemaktosilin was carried out after 48 hours incubation. Light microscopy was used for counting the cells that pass through the membrane. Normality and homogeneity data were determined by Saphiro-wilk test and Levene test. Data was analyzed by One Way ANOVA and was continue by Post Hoc with LSD test. The result of apoptosis showed that there were significant differences apoptotic cell mean (p<0,05). Furthermore, the result of invasion cell inhibition showed that there were significant differences invasion cell inhibition mean (p<0,05). and invasion resistance of oral tongue squamous cell carcinoma cell line (SP-C1). In conclusion, pomegranate ethanol extract induced apoptosis of oral tongue squamous cell carcinoma and the increases of pomegranate ethanol extract concentration followed by the increases of apoptosis induction. Pomegranate ethanol extract also inhibited invasion of oral tongue squamous cell carcinoma and the increases of pomegranate ethanol extract concentration followed by the increases of invasion cell inhibition

GAMBARAN KEJADIAN INFEKSI NOSOKOMIAL DAN FAKTOR RISIKO BERDASARKAN PEMETAAN SISTIM INFORMASI GEOGRAFIS DI RUANG RAWAT INAP RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG

Background: Hospitalized patients at very high risk for the occurrence of nosocomial infections due to various reasons. They tend to be more susceptible to infection because of their underlying disease condition, but their risk is compounded when patients undergo invasive procedures. If the patient's immune system is impaired, it is usually not pathogenic microorganism capable of causing disease. Map illustrating the data are epidemiologic methods to convey specific data easily and quickly. Maps can be used to show where a disease or event occurs. Mapping the incidence of nosocomial infections in Hospital Sultan Agung is a method developed for the surveillance of nosocomial infections. Methods This type of research is a quantitative study with a cross sectional study. This study illustrates the risk factors of nosocomial infection with incidence of nosocomial infections that occur based on time point. Risk factors are factors extrinsic and intrinsic factors. Results: Based on the spatial image on the map, in Extrinsic incidence of nosocomial infections is Plebitis many blades. Genesis Plebitis occurred related to the placement of hand washing points handrub, disproportionate ratio between the number of nurses with patients and patient care time in the hospital. While the intrinsic factor in the picture Plebitis most inpatient distribution in patients aged 50 years with impaired skin integrity due to infusion and physically due to decreased immunity associated with a variety of underlying diseases. Conclusion: incidence of nosocomial infections in the inpatient unit is the primary predisposing factors such as age and clinical issues related predisposing underlying disease can weaken the immune system of the patient, so that the procedures and even the most basic medical treatment could potentially cause nosocomial infection

PERBEDAAN RADIOPASITAS ANTARA SEALER BERBAHAN DASAR RESIN EPOKSI DAN SEALER BERBAHAN DASAR SENG OKSID EUGENOL DENGAN TEKNIK RADIOGRAFI PERIAPIKAL DIGITAL

Radiopacity is the inability of X-rays to penetrate material that causes radiopaque. Sealer, along with gutta percha, is used as a root canal filling material. Then, obturation process of the root canal treatment was evaluated by radiograph. Therefore, the sealer must be radiopaque to difference with anatomy structure in the radiograph. The aim of this study was to determine the difference of radiopacity between epoxy resin based sealer compared with zinc oxide eugenol based sealer on digital periapical radiography techniques. Twenty sealer study samples were divided into two groups. Group I consisted of 10 samples of epoxy resin based sealer . Group II consisted of 10 samples of zinc oxide eugenol based sealer. Images were taken from both groups by using radiograph technique with periapical digital radiographic techniques with the specification of 50 kVp, 7mA , and 0.8 seconds. Observations were carried out using the Image J software. The results of calculations were analyzed by using the Independent t - test. The results showed that significant radiopacity differences were occurred in both groups (p < 0.05). Epoxy resin based sealer (6,85 mmAl) was significantly more radiopaque than zinc oxide eugenol based sealer (3,22 mmAl). Radiopacity was influenced of chemical composition, inorganic contrast medium, atom number, and the density of the sealer. The conclusion of this study is that epoxy resin based sealer is more radiopaque than zinc oxide eugenol based sealer. Keywords: radiopacity, sealer, radiography, periapical, digital

DAYA ANTIBAKTERI EKSTRAK KAYU SIWAK (Salvadora persica) SEBAGAI BAHAN IRIGASI SALURAN AKAR TERHADAP Pseudomonas aeruginosa

Root canal treatment is a treatment that aims to maintain vital tooth or necrosis tooth. One of step in the root canal treatment process is root canal irrigation. The purpose of irrigation is for cleaning the root canal from necrotic pulp tissue, the dentine debris, the bacteria and the bacterial products. Pseudomonas aeruginosa is one of the gram-negative bacteria, which is found in infected root canals. The siwak extract has antibacterial ability against some gram-positive and gram-negative bacteria. This study is aimed to determine the optimum antibacterial ability of the siwak extract as root canal irrigation compound. Siwak extract diluted to a concentration of 10%, 15%, 20%, 30%, 40%, 50%, and a solution of 2% Chlorhexidine as a positive control and distilled water as a negative control were dropped into agar wells in a petri dish containing agar medium and bacteria. Each test solution was done in six times repetition. Agar mediums that have been filled with the test mediums in the agar wells were then incubated for 24 hours with a temperature of 370C. After incubation, the radical zone formed around the agar wells were measured by used a vernier caliper. Measurement data were analyzed with Kruskal-Wallis and Mann-Whitney test. The results showed that siwak extracts with concentration 10%, 15%, 20%, 30%, 40%, 50% have different radical zone area. Relationships between two groups of test solution showed a significant difference (p <0.05). The conclusion of this study is siwak extract concentrations of 10%, 15%, 20%, 30%, 40%, 50% has antibacterial ability against Pseudomonas aeruginosa, with the 50% concentration having the best antibacterial ability. Key word : Siwak, Root canal treatment, P. aeruginos